Metabolic Function | Osteoarthritis

Turmeric

700 mg
,
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  • Improvement in fat and sugar levels
  • Pain reduction in osteoarthritis
  • Potential reduction in cognitive decline

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Why we recommend

To assess the benefits of turmeric, we compared results from multiple systematic reviews that review the literature.1,2,3,4,5,6,7 Turmeric has long been used in eastern medicine, but what do the randomized controlled trials say?

For metabolic syndrome, pre-diabetes, and type II diabetes, all systematic reviews we found show improvements in blood pressure, HbA1c levels, fat levels, cholesterol, and more.1,5,6,7. Each of these systematic reviews combined data from randomized controlled trials to find statistically significant reductions across these critical metabolic indicators.

For patients with osteoarthritis, pain and function was improved in a meta-analyses across 10 randomized controlled trials.1,8

Turmeric may even help reduce cognitive decline, but more research is needed in this area.2

Note that the Rolfe article has a conflict of interest. However, none of our claims are based on the Rolfe article alone, since other reviews support the same findings.

Research benefits

Metabolic Syndrome
Positive impact
Highlights:

Patients with metabolic syndrome in multiple meta-analyses had a statistically significant reduction in blood pressure across pooled data from 7+ systematic reviews. (1,5) Other health indicators were improved as well across multiple meta-analyses, including triglyceride (fat) levels, BMI, waist circumference, total cholesterol, leptin, and others. (1,5,7)

Another meta-analysis found statistically significant positive impacts on BMI, weight, leptin levels, and adiponectin levels using data spanning 21 randomized controlled trials (6).

Source: Rolfe, 2020 (1). Azhdari, 2019 (5). Akbari, 2019 (6). Chien, 2021 (7)

Osteoarthritis
Positive impact
Highlights:

Curcumin statistically significantly reduced pain and helped reinstate physical function / mobility in osteoarthritis patients when compared to placebo. Data was aggregated across 10 randomized controlled trials in Paultre (8) and seven systematic reviews in Rolfe (1).

Source: Rolfe, 2020 (1); Paultre, 2021 (8).

Diabetes
Positive impact
Highlights:

Patients with pre-diabetes or type 2 diabetes had a statistically significant reduction in HbA1C across pooled data from 12 systematic reviews.

Source: Rolfe, 2020 (1).

Alzheimer's Disease
Positive or no impact
Highlights:

3 of 5 studies in healthy, non-demented elderly found either reduced cognitive decline or improved cognitive performance over time, relative to placebo

Source: Voulgaropoulou, 2019 (2).

Harms
Risk of mild GI side effects
Highlights:

23 systematic reviews reported no serious adverse events; 15 reviews detailed adverse events which were all minor and included GI symptoms (nausea, diarrhea), headaches, sleepiness, hypertension, etc.

Source: Rolfe, 2020 (1).

References

    References

    1. Rolfe, V., Mackonochie, M., Mills, S., & MacLennan, E. (2020). Turmeric / curcumin and health outcomes: A meta-review of systematic reviews. European Journal of Integrative Medicine, 40. https://doi.org/https://doi.org/10.1016/j.eujim.2020.101252
    2. Voulgaropoulou SD, van Amelsvoort TAMJ, Prickaerts J, Vingerhoets C. The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Res. 2019 Dec 15;1725:146476. doi: 10.1016/j.brainres.2019.146476. Epub 2019 Sep 24. PMID: 31560864.
    3. Vafaeipour Z, Razavi BM, Hosseinzadeh H. Effects of turmeric (Curcuma longa)and its constituent (curcumin) on the metabolic syndrome: An updated review. J Integr Med. 2022; 20(3):193–203.
    4. C. Michael White, Vinay Pasupuleti, Yuani M. Roman, Yangzhou Li, Adrian V. Hernandez, Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: A systematic review and meta-analysis of randomized controlled trials, Pharmacological Research, Volume 146, 2019, 104280, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2019.104280.
    5. Azhdari M, Karandish M, Mansoori A. Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019 May;33(5):1289-1301. doi: 10.1002/ptr.6323. Epub 2019 Apr 2. PMID: 30941814.
    6. Akbari M, Lankarani KB, Tabrizi R, Ghayour-Mobarhan M, Peymani P, Ferns G, Ghaderi A, Asemi Z. The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2019 Jun 12;10:649. doi: 10.3389/fphar.2019.00649. PMID: 31249528; PMCID: PMC6582779.
    7. Chien YJ, Chang CY, Wu MY, Chen CH, Horng YS, Wu HC. Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis. Nutrients. 2021 Feb 21;13(2):684. doi: 10.3390/nu13020684. PMID: 33669954; PMCID: PMC7924860.
    8. Paultre K, Cade W, Hernandez D, et al. Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: a systematic review. BMJ Open Sport & Exercise Medicine 2021;7:e000935. doi: 10.1136/bmjsem-2020-000935
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